--- title: Modo de uso description: Conoce el aval científico de Rhinodouche®. Descubre los estudios médicos y la evidencia clínica que respaldan nuestra solución para rinitis y sinusitis. --- [Skip to main content](https://www.rhinodouche.co/es/aval-cientifico#main-content) **Esta página es de uso exclusivo para Colombia.** ![COLOMBIA](https://www.rhinodouche.co/hs-fs/hubfs/COLOMBIA.png?width=18&height=18&name=COLOMBIA.png)   [![Rhinodouche logo\_vector](https://www.rhinodouche.co/hubfs/Rhinodouche%20logo_vector.svg) ![Rhinodouche logo\_vector](https://www.rhinodouche.co/hubfs/Rhinodouche%20logo_vector.svg) ![Rhinodouche logo\_vector](https://www.rhinodouche.co/hubfs/Rhinodouche%20logo_vector.svg) ![Rhinodouche logo\_vector](https://www.rhinodouche.co/hubfs/Rhinodouche%20logo_vector.svg)](https://www.rhinodouche.co/es/home?hsLang=es) - Esta página es de uso exclusivo para Colombia. Open main navigation Close main navigation - Esta página es de uso exclusivo para Colombia. - [Indicaciones](https://www.rhinodouche.co/es/indicaciones) [Modo de uso](https://www.rhinodouche.co/es/modo-de-uso) [Comprar](https://wa.me/message/M7DSBQXVOAAAK1) [Indicaciones](https://www.rhinodouche.co/es/indicaciones?hsLang=es) [Modo de uso](https://www.rhinodouche.co/es/modo-de-uso?hsLang=es) [Comprar](https://wa.me/message/M7DSBQXVOAAAK1) [🏠Rhinodouche® Dispositivo / Aval Científico](https://www.rhinodouche.co/?hsLang=es)   ### Aval Científico ###### Aclaramiento mucociliar - **Jiao J, Yang J, Li Y, Zhang L.** *Hypertonic saline and seawater solutions damage sinonasal epithelial cell air‐liquid interface cultures.* International Forum of Allergy; Rhinology. 2019;10(1):59-68. - **Sauvalle, M. and Alvo, A., 2018.** *Effect of the temperature of nasal lavages on mucociliary clearance: a randomised controlled trial.* European Archives of Oto-Rhino-Laryngology, 275(9), pp.2403-2406. - **Piromchai, P., Kasemsiri, Laohasiriwong and Thanaviratananich, 2013.** *Chronic rhinosinusitis and emerging treatment options. International Journal of General Medicine, p.453.* - **Sindwani, R., 2010.** *Impact of isotonic and hypertonic saline solutions on mucociliary activity in various nasal pathologies: clinical study.* Yearbook of Otolaryngology-Head and Neck Surgery, 2010, pp.205-206. - **Hauptman, G. and Ryan, M., 2007.** *The effect of saline solutions on nasal patency and mucociliary clearance in rhinosinusitis patients.* Otolaryngology–Head and Neck Surgery, 137(5), pp.815-821. - **Cohen, N., 2006.** *Sinonasal Mucociliary Clearance in Health and Disease.* Annals of Otology, Rhinology; Laryngology, 115(9), pp.20-26 - **Boek, W., Graamans, K., Natzijl, H., van Rijk, P. and Huizing, E., 2002.** *Nasal Mucociliary Transport: New Evidence for a Key Role of Ciliary Beat Frequency.* The Laryngoscope, 112(3), pp.570-573. ###### Cirugía nasal - **de Paiva Leite S, Douglas R.** *How does sinus surgery affect topical irrigation distribution?.* Current Opinion in Otolaryngology Head; Neck Surgery. 2018;26(1):21-26. - **Giotakis A, Karow E, Scheithauer M, Weber R, Riechelmann H.** *Saline irrigations following sinus surgery a controlled, single blinded, randomized trial.* Rhinology journal. 2016;54(4):302-310. - **Low T, Woods C, Ullah S, Carney A.** *A Double-Blind Randomized Controlled Trial of Normal Saline, Lactated Ringer’s, and Hypertonic Saline Nasal Irrigation Solution after Endoscopic Sinus Surgery.* American Journal of Rhinology; Allergy. 2014;28(3):225-231. - **Kim S, Sung U, Jung J, Paik J, Woo J, Cha H et al.** *The Effect of Maxillary Sinus Irrigation on Early Prognostic Factors after Endoscopic Sinus Surgery: A Preliminary Study.* American Journal of Rhinology; Allergy. 2013;27(5):e158-e161. - **Rudmik L, Soler Z, Orlandi R, Stewart M, Bhattacharyya N, Kennedy D et al.** *Early postoperative care following endoscopic sinus surgery: an evidence-based review with recommendations.* International Forum of Allergy & Rhinology. ###### Embarazo - **Namazy JA, Schatz M.** Asthma and rhinitis during pregnancy. Mt Sinai J Med. 2011 Sep-Oct;78(5):661-70. doi: 10.1002/msj.20284. PMID: 21913197. - **Garavello W, Somigliana E, Acaia B, Gaini L, Pignataro L, Gaini RM**. Nasal lavage in pregnant women with seasonal allergic rhinitis: a randomized study. Int Arch Allergy Immunol. 2010;151(2):137-41. doi: 10.1159/000236003. Epub 2009 Sep 15. PMID: 19752567. - **Incaudo GA, Takach P.** The diagnosis and treatment of allergic rhinitis during pregnancy and lactation. Immunol Allergy Clin North Am. 2006 Feb;26(1):137-54. doi: 10.1016/j.iac.2005.10.005. PMID: 16443148 - **Ellegård EK**. Pregnancy rhinitis. Immunol Allergy Clin North Am. 2006 Feb;26(1):119-35, vii. doi: 10.1016/j.iac.2005.10.007. PMID: 16443147. - **Ellegård EK**. The etiology and management of pregnancy rhinitis. Am J Respir Med. 2003;2(6):469-75. doi: 10.1007/BF03256674. PMID: 14719986. - **Schatz M, Zeiger RS.** Asthma and allergy in pregnancy. Clin Perinatol. 1997 Jun;24(2):407-32. PMID: 9209810. ###### Irrigación nasal como agente vehiculizante de otros fármacos y tratamientos - **Harvey R, Snidvongs K, Kalish L, Oakley G, Sacks R.** *Corticosteroid nasal irrigations are more effective than simple sprays in a randomized double-blinded placebo-controlled trial for chronic rhinosinusitis after sinus surgery.* International Forum of Allergy; Rhinology. 2018;8(4):461-470. - **Tugrul S, Dogan R, Eren S, Meric A, Ozturan O.** *The use of large volume low pressure nasal saline with fluticasone propionate for the treatment of pediatric acute rhinosinusitis.* International Journal of Pediatric Otorhinolaryngology. 2014;78(8):1393-1399. - **Liang J, Lane A.***Topical Drug Delivery for Chronic Rhinosinusitis.* Current Otorhinolaryngology Reports. 2012;1(1):51-60. ###### Irrigación nasal en infecciones víricas - **Baxter AL, Schwartz KR, Johnson RW, et al.** *Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients.* Ear Nose Throat J. 2022 - **Radulesco T, Lechien JR, et al.** *Safety and Impact of Nasal Lavages During Viral Infections Such as SARS-CoV-2.* Ear Nose Throat J. 2021 Apr;100(2\_suppl):188S-191S. - **Singh S, Aggarwal P, Ravichandiran V.** *Immunological Response of the Respiratory Tract in the SARS-CoV-2 Infection.* Coronaviruses. 2021;2(9). - **Farrell N, Klatt-Cromwell C, Schneider J.** *Benefits and Safety of Nasal Saline Irrigations in a Pandemic—Washing COVID-19 Away.* JAMA Otolaryngology–Head; Neck Surgery. 2020;146(9):787. - **Ramalingam S, Graham C, Dove J, Morrice L, Sheikh A.** *Hypertonic saline nasal irrigation and gargling should be considered as a treatment option for COVID-19.* Journal of Global Health. 2020;10(1). - **Ramalingam S, Graham C, Dove J, Morrice L, Sheikh A.** *A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold.* Scientific Reports. 2019;9(1). ###### Irrigación nasal vs. nebulizadores/sprays nasales - **Piromchai P et al.** *Squeeze bottle versus syringe nasal saline irrigation for persistent allergic rhinitis – a randomized controlled trial.* Rhinology 2020; 58(5):460-464. - **Gabory L, Kérimian M, Baux Y, Boisson N, Bordenave L.** *Computational fluid dynamics simulation to compare large volume irrigation and continuous spraying during nasal irrigation.* International Forum of Allergy; Rhinology. 2019;10(1):41-48. - **Piromchai P, Puvatanond C, Kirtsreesakul V, Chaiyasate S, Thanaviratananich S.** *Effectiveness of nasal irrigation devices: a Thai multicentre survey.* PeerJ. 2019;7:e7000. - **Low TH, Woods CM, Ullah S, Carney AS.** A double-blind randomized controlled trial of normal saline, lactated Ringer’s, and hypertonic saline nasal irrigation solution after endoscopic sinus surgery. Am J Rhinol Allergy. 2014 May-Jun;28(3):225-31. doi: 10.2500/ajra.2014.28.4031. Epub 2014 Jan 16. PMID: 24598116. - **Snidvongs K, Thanaviratananich S.** *Update on Intranasal Medications in Rhinosinusitis.* Current Allergy and Asthma Reports. 2017;17(7). - **Campos J, Heppt W, Weber R.** *Nasal douches for diseases of the nose and the paranasal sinuses—a comparative in vitro investigation.* European Archives of Oto-Rhino-Laryngology. 2013;270(11):2891-2899. - **Sindwani R.** *Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Yearbook of Otolaryngology-Head and Neck Surgery.* 2008;2008:209-210. - **Wormald P, Cain T, Oates L, Hawke L, Wong I.** *A Comparative Study of Three Methods of Nasal Irrigation. The Laryngoscope.* 2004;114(12):2224-2227. ###### Pediatría - **Jung M, Lee JY, Ryu G, Lee KE, Hong SD, Choi J, Kim S, Ahn K, Dhong HJ, Chung SK, Kim J, Kim HY.** *Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial.* Asian Pac J Allergy Immunol. 2020 Dec;38(4):251-257. - **Chandy Z, Ference E, Lee J.** *Clinical Guidelines on Chronic Rhinosinusitis in Children.* Current Allergy and Asthma Reports. 2019;19(2). - **Fokkens W, Desrosiers M, Harvey R, et al.EPOS2020:** development strategy and goals for the latest European Position Paper on Rhinosinusitis. Rhinology. 2019 Jun 1;57(3):162-168. doi: 10.4193/Rhin19.080. PMID: 30810118. - **Satdhabudha A, Utispan K, Monthanapisut P, Poachanukoon O.A** randomized controlled study comparing the efficacy of nasal saline irrigation devices in children with acute rhinosinusitis. Asian Pac J Allergy Immunol. 2017 Jun;35(2):102-107. doi: 10.12932/AP0753. PMID: 27543734. - **Ragab A, Farahat T, Al-Hendawy G, Samaka R, Ragab S, El-Ghobashy A.** *Nasal saline irrigation with or without systemic antibiotics in treatment of children with acute rhinosinusitis.* International Journal of Pediatric Otorhinolaryngology. 2015;79(12):2178-2186. - **King D, Mitchell B, Williams CP, Spurling GK.** Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Database Syst Rev. 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369; PMCID: PMC9475221. - **Wang YH, Ku MS, Sun HL, Lue KH.** Efficacy of nasal irrigation in the treatment of acute sinusitis in atopic children. J Microbiol Immunol Infect. 2014 Feb;47(1):63-9. doi: 10.1016/j.jmii.2012.08.018. Epub 2012 Sep 30. PMID: 23034126. - **Pham V, Sykes K, Wei J.** *Long-term outcome of once daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis.* The Laryngoscope. 2013;124(4):1000-1007. - **Jeffe J, Bhushan B, Schroeder J.** *Nasal saline irrigation in children: A study of compliance and tolerance.* International Journal of Pediatric Otorhinolaryngology. 2012;76(3):409-413. - **Wei J, Sykes K, Johnson P, He J, Mayo M.** *Safety and efficacy of once-daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis.* The Laryngoscope. 2011;121(9):1989-2000. - **Yun-Hu Wang, Chun-Ping Yang, et al.** Efficacy of nasal irrigation in the treatment of acute sinusitis in children. International Journal of Pediatric Otorhinolaryngology, Vol 73, Issue 12,2009,Pages 1696-1701, ISSN 0165-5876. - **Slapak I, Skoupá J, Strnad P, Horník P.** Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children. Arch Otolaryngol Head Neck Surg. 2008 Jan;134(1):67-74. doi: 10.1001/archoto.2007.19. PMID: 18209140. ###### Rinitis alérgica - **Ana Martínez-Serrano, Paloma Martínez-Campos, Laura Seijoso-González, Héctor Ruiz-Rojo.** Revisión narrativa de la técnica de los lavados nasales en pediatría. Enfermería Clínica, Volume 31, Issue 3,2021, Pages 189-194. - **Jung M, Lee JY, Ryu G, Lee KE, Hong SD, Choi J, Kim S, Ahn K, Dhong HJ, Chung SK, Kim J, Kim HY.** *Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial.* Asian Pac J Allergy Immunol. 2020 Dec;38(4):251-257. - **Head K, Snidvongs K, Glew S, Scadding G, Schilder A, Philpott C et al.** *Saline irrigation for allergic rhinitis.* Cochrane Database of Systematic Reviews. 2017. - **Nguyen S, Psaltis A, Schlosser R.** *Isotonic Saline Nasal Irrigation is an Effective Adjunctive Therapy to Intranasal Corticosteroid Spray in Allergic Rhinitis.* American Journal of Rhinology; Allergy. 2014;28(4):308-311. - **Roberts G, Xatzipsalti M, et al.Paediatric rhinitis**: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013 Sep;68(9):1102-16. doi: 10.1111/all.12235. Epub 2013 Aug 19. PMID: 23952296. - **Wang YH, Ku MS, et al.** Efficacy of nasal irrigation in the treatment of acute sinusitis in atopic children. J Microbiol Immunol Infect. 2014 Feb;47(1):63-9. doi: 10.1016/j.jmii.2012.08.018. Epub 2012 Sep 30. PMID: 23034126. - **Hermelingmeier KE, Weber RK et al.** Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. 2012 Sep-Oct;26(5):e119-25. doi: 10.2500/ajra.2012.26.3787. PMID: 23168142; PMCID: PMC3904042. ###### Sinusitis - **Chandy Z, Ference E, Lee J.** *Clinical Guidelines on Chronic Rhinosinusitis in Children.* Current Allergy and Asthma Reports. 2019;19(2). - **Fokkens W, Desrosiers M, et al.** EPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis. 2019 Jun 1;57(3):162-168. doi: 10.4193/Rhin19.080. PMID: 30810118. - **Hopkins C.** *Chronic Rhinosinusitis with Nasal Polyps.* New England Journal of Medicine. 2019;381(1):55-63. - **Beswick DM, Messner AH, Hwang PH**. Pediatric Chronic Rhinosinusitis Management in Rhinologists and Pediatric Otolaryngologists. Ann Otol Rhinol Laryngol. 2017 Sep;126(9):634-639. doi: 10.1177/0003489417719717. Epub 2017 Aug 2. PMID: 28766959. - **Zakrzewska A.** *Diagnosis and treatment of Chronic Rhinosinusitis in Children according European Position Paper on Rhinosinusitis and nasal Polyps –EPOS-2012 and American Academy Otolaryngology-Head and Neck Surgery 2014.* Polski Przegląd Otorynolaryngologiczny. 2018;7(2):27-32. - **Rudmik L, Soler Z.** *Medical Therapies for Adult Chronic Sinusitis.* JAMA. 2015;314(9):926. - **Ragab A, Farahat T, Al-Hendawy G, Samaka R, Ragab S, El-Ghobashy A.** *Nasal saline irrigation with or without systemic antibiotics in treatment of children with acute rhinosinusitis.* International Journal of Pediatric Otorhinolaryngology. 2015;79(12):2178-2186. - **Pham V, Sykes K, Wei J.** *Long-term outcome of once daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis.* The Laryngoscope. 2013;124(4):1000-1007. - **Hong SD, Kim JH, Kim HY, Jang MS, Dhong HJ, Chung SK.** Compliance and efficacy of saline irrigation in pediatric chronic rhinosinusitis. Auris Nasus Larynx. 2014 Feb;41(1):46-9. doi: 10.1016/j.anl.2013.07.008. Epub 2013 Aug 8. PMID: 23932052. - **Wei J, Sykes K, Johnson P, He J, Mayo M.** *Safety and efficacy of once-daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis.* The Laryngoscope. 2011;121(9):1989-2000. - **Jeffe JS, Bhushan B, Schroeder JW Jr.Nasal saline irrigation in children:** a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol. 2012 Mar;76(3):409-13. doi: 10.1016/j.ijporl.2011.12.022. Epub 2012 Jan 21. PMID: 22266167. - **Rosenfeld R. Clinical Practice Guideline on Adult Sinusitis.** *Otolaryngology–Head and Neck Surgery.* 2007;137(3):365-377. - **Scadding G, Durham S, Mirakian R, Jones N, Drake-Lee A, Ryan D et al.** *BSACI guidelines for the management of rhinosinusitis and nasal polyposis.* Clinical; Experimental Allergy. 2007;38(2):260-275. --- --- Rhinodouche® Dispositivo ALTO PODER DE ARRASTRE [Irrigación nasal](https://www.rhinodouche.co/m%C3%A1s-informaci%C3%B3n?hsLang=es) [Indicaciones](https://www.rhinodouche.co/indicaciones?hsLang=es) [Modo de uso](https://www.rhinodouche.co/modo-de-uso?hsLang=es) [Comprar](https://wa.link/34i1uz) [Aval científico](https://www.rhinodouche.co/aval-cientifico?hsLang=es) [Preguntas frecuentes](https://www.rhinodouche.co/preguntas-frecuentes-de-uso?hsLang=es) El contenido de este sitio web está destinado exclusivamente al público en Colombia. © Derechos de autor 2026 – Rhinodouche® | Todos los derechos reservados. 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